Pharmacological Evaluation of Different Extracts of Asparagus officinalis (Asparagaceae) as an Analgesic, Anti-Inflammatory and Anti-arthritic Agent in Rats

Pharmacognosy Research,2023,15,1,184-205.DOI:10.5530/097484900333Published:December 2022Type:Original ArticleAuthors:Satish Kumar, Pratima Srivastava, Sumeet Gupta, Meenakshi Dhanawat, Sapna Rani, Basiru Olaitan Ajiboye, and Rupesh K Gautam Author(s) affiliations:Satish Kumar1, Srivastava2, Gupta1,*, Dhanawat3, Rani1, Ajiboye4, Gautam5 1M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Haryana, INDIA. 2Aragen Life Sciences Private Limited, Hyderabad, Telangana, INDIA 3Amity Institute Amity University, Maneswar, Gurugram, 4Phytomedicine Molecular Research , Federal University Oye-Ekiti, NIGERIA. 5Indore institute IIST campus, Indore, Madhya Pradesh, Abstract:Background: To treat the joint pain arial part Asparagus officinalis (asparagus) has historically been used. However, its efficacy for rheumatoid arthritis not pharmaceutically evaluated. We explore phytochemical analysis anti-inflammatory, analgesic anti-arthritic activity petroleum ether, ethanol aqueous extracts aerial part. Materials Methods: Tail- flick method was used evaluate anti-inflammatory carried out using paw oedema induced with carrageenan CFA arthritic model potential in anti- rats. The Petroleum ethanolic were dosed orally three divided doses (75, 150 300 mg/ kg). For inflammatory diclofenac sodium at 10 mg/kg as standard, whereas prednisolone 5 methotrexate 0.5 kg standard. One-way ANOVA followed by Dunnett’s multiple range test analyse statistical significance between means. Results: results revealed a dosecontrolled effect different some extent observed. Four compounds present confirmed LCMS/MS. model's findings showed improved defence against lesions changes body weight. Additionally, significantly factor, changed WBCs, favourably altered radiographic histological alterations. Conclusion: indicate that is strong compound may suggested treatment both chronic acute inflammation. Keywords:Carrageenan, Chemical constituents, LCMS/MS, Rheumatoid Arthritis, Sparrow grass.View:PDF (1.47 MB)